Open Trials

A Funded Clinical Trial to Evaluate a Novel Immunotherapy in Dogs with Lymphoma, Melanoma and Mast Cell Tumors

m1Trial Specifics
This trial is designed to evaluate the safety and preliminary anti-cancer activity of a novel, monoclonal antibody in dogs with measurable cancer. The antibody is administered IV by the study staff every 28 days for up to 5 treatments. There is no placebo in this trial. An estimated 30 client-owned dogs with Lymphoma, Melanoma, or Mast Cell Tumors will be enrolled. Visits will be required when the dogs begin the study, at Day 14, Day 28, and monthly thereafter for a total trial period of 140 days.

Trial Funding
The trial is fully funded for the full trial duration (140 days), including the antibody and trial-related procedures.

Trial Eligibility
Dogs with one of the following cancers may be enrolled if they meet the specific criteria for each cancer:

Mast Cell tumors

  • At least one measurable skin tumor +/- metastatic lymph node(s) ≥ 2 cm
  • No intraabdominal metastasis
  • Prior therapy accepted with washout times to be discussed with the participating site


  • At least one measurable malignant tumor in the oral cavity, digit, skin +/- metastatic lymph node ≥ 2 cm
  • No pulmonary metastasis
  • Prior therapy accepted with washout times to be discussed with participating site


  • All stages accepted but must have at least one measurable peripheral lymph node ≥ 2 cm
  • No pulmonary or gastrointestinal involvement
  • Disseminated B or T-cell lymphoma (not epitheliotrophic)
  • Newly diagnosed or dogs that have completed no more than one chemotherapy protocol

Trial Location
The clinical trial is being offered at the following location:

The Oncology Service at The LifeCentre
134 Fort Evans Rd. NE
Leesburg VA 20176

The Veterinary Cancer Center
129 Glover Ave
Norwalk CT 06850

Veterinary Specialty Hospital of San Diego
10435 Sorrento Valley Rd
San Diego CA 92121

VCA Katonah Bedford Veterinary Center
546 Bedford Rd. (Route 117)
Bedford Hills NY 10507

University of Wisconsin-Madison
School of Veterinary Medicine

2015 Linden Drive
Madison WI 53706

BluePearl Overland Park
11950 West 110th St
Overland Park KS 66210

Oradell Animal Hospital
580 Winters Ave
Paramus NJ 07652

Hope Veterinary Specialists
40 Three Tun Rd
Malvern PA 19355

Las Vegas Veterinary Specialty Center
8650 W. Tropicana Ave, Suite B-107
Las Vegas NV 89147

Blood Sample Collection Study from Dogs with Atopic Dermatitis

ACI is conducting a pilot, blood sample collection study in dogs with atopic dermatitis. No therapy is involved in this study.

Canine atopic dermatitis is a common disorder that causes pronounced itchy skin; particularly the paws and ears. The study is designed to evaluate serum of dogs with this disorder in order to explore novel therapeutic approaches. It is anticipated that 150 dogs will enroll. Each dog will have a small blood sample (3 ml) collected at a single timepoint. There is no charge to the owner for obtaining the sample.

The following dermatology specialty clinics are participating in this study:

Dermatology for Animals
86 West Juniper Ave
Gilbert AZ 85233
(480) 633-2277

Dermatology for Animals
4000 Montgomery Blvd, NE
Albuquerque NM 87109
(505) 881-7205

Dermatology for Animals
106 East Campbell Avenue
Campbell CA 95008
(408) 871-3800

Animal Dermatology Clinics
5610 Kearny Mesa Rd, #B1
San Diego CA 92111
(858) 560-9393

Dermatology for Animals
9706 Mockingbird Dr
Omaha NE 68127
(402) 614-9000

410 West 55th Street
New York NY 10019
(212) 767-0099

Dermatology for Animals
1321 Centerview Cir
Akron OH 44321
(330) 238-1820

University of Wisconsin – Madison
School of Veterinary Medicine
2015 Linden Dr. Madison WI 53706
(608) 263-7600

Dermatology for Animals
825 White Spruce Blvd
Rochester NY 14623
(877) 604-8366

Southeast Veterinary Dermatology Clinic
1131 Queensborough Blvd, Suite 100
Mt. Pleasant SC 29464
(843) 849-7770

455 Abernathy Rd NE
Atlanta GA
(404) 459-0903

1100 Eden Way North
Chesapeake VA 23320
(757) 366-9000

Great Pyrenees with Osteosarcoma

ACI is conducting a study that collects saliva sample, buccal (cheek) swabs, and a small amount of whole blood from Great Pyrenees that are diagnosed with Osteosarcoma. Eligible dogs may be newly diagnosed, currently receiving therapy, or previously treated.

Trial Eligibility:

  • Any purebred Great Pyrenees with Osteosarcoma
  • Any age, breed, or sex is eligible

Trial Support

This study is a voluntary study for pet owners whose dogs meet the above criteria.

Saliva collection kits and buccal swabs will be provided to pet owners at no charge with sampling and mailing instructions inside. A kit with prepaid return packaging will be mailed to the owners for quick and easy return. Blood samples are requested, but not mandatory. Please contact ACI for information on how a blood samples can be obtained in your area.