A Funded Clinical Trial to Evaluate a Novel Immunotherapy in Dogs with Lymphoma, Melanoma and Mast Cell Tumors

m1Trial Specifics
This trial is designed to evaluate the safety and preliminary anti-cancer activity of a novel, monoclonal antibody in dogs with measurable cancer. The antibody is administered IV by the study staff every 28 days for up to 5 treatments. There is no placebo in this trial. An estimated 30 client-owned dogs with Lymphoma, Melanoma, or Mast Cell Tumors will be enrolled. Visits will be required when the dogs begin the study, at Day 14, Day 28, and monthly thereafter for a total trial period of 140 days.

Trial Funding
The trial is fully funded for the full trial duration (140 days), including the antibody and trial-related procedures.

Trial Eligibility
Dogs with one of the following cancers may be enrolled if they meet the specific criteria for each cancer:

Mast Cell tumors

  • At least one measurable skin tumor +/- metastatic lymph node(s) ≥ 2 cm
  • No intraabdominal metastasis
  • Prior therapy accepted with washout times to be discussed with the participating site

Melanoma

  • At least one measurable malignant tumor in the oral cavity, digit, skin +/- metastatic lymph node ≥ 2 cm
  • No pulmonary metastasis
  • Prior therapy accepted with washout times to be discussed with participating site

Lymphoma

  • All stages accepted but must have at least one measurable peripheral lymph node ≥ 2 cm
  • No pulmonary or gastrointestinal involvement
  • Disseminated B or T-cell lymphoma (not epitheliotrophic)
  • Newly diagnosed or dogs that have completed no more than one chemotherapy protocol

Trial Location
The clinical trial is being offered at the following location:

The Oncology Service at The LifeCentre
134 Fort Evans Rd. NE
Leesburg VA 20176
571-209-1176

The Veterinary Cancer Center
129 Glover Ave
Norwalk CT 06850
203-838-6626

Veterinary Specialty Hospital of San Diego
10435 Sorrento Valley Rd
San Diego CA 92121
858-875-7500

VCA Katonah Bedford Veterinary Center
546 Bedford Rd. (Route 117)
Bedford Hills NY 10507
914-241-7700

University of Wisconsin-Madison
School of Veterinary Medicine

2015 Linden Drive
Madison WI 53706
608-263-7600

BluePearl Overland Park
11950 West 110th St
Overland Park KS 66210
913-642-9563

Oradell Animal Hospital
580 Winters Ave
Paramus NJ 07652
201-262-0010

Hope Veterinary Specialists
40 Three Tun Rd
Malvern PA 19355
610-296-2099

Las Vegas Veterinary Specialty Center
8650 W. Tropicana Ave, Suite B-107
Las Vegas NV 89147
702-871-1152