Conditionally Licensed Monoclonal Antibody +
 Multi-agent Chemotherapy for Dogs with T-Cell Lymphoma

ACI is currently enrolling cases in a nationwide clinical trial to evaluate a monoclonal antibody (AT-005) 
that is conditionally licensed by the USDA to aid in the treatment of dogs with lymphoma. The study is designed to assess the benefit of adding AT-005 to a multi-agent chemotherapy protocol for dogs with intermediate to high grade T-cell lymphoma.

 

CLINICAL STUDY DETAILS

Trial Summary

An estimated 48 client-owned dogs will be enrolled 
in this study. All enrolled dogs will receive multi-agent chemotherapy (CHOP protocol), which will be supplemented by either placebo or the monoclonal antibody. Dogs will be randomized equally (1:1) to receive antibody or placebo during the chemotherapy protocol and the veterinary oncologist performing 
the dogs’ evaluations will be blinded to their group assignment. Study visits are required twice weekly for four weeks, once weekly for another 15 weeks, and monthly thereafter. The study duration is 18 months; however, if progressive disease occurs before the 18-month visit, dogs will be removed from the study at that time.

 

Trial Funding

Dogs presenting to the participating trial site will 
be screened for enrollment. The pet owner will be financially responsible for the initial consultation, blood/ urine analysis, and thoracic radiographs. A lymph node biopsy and flow cytometry analysis will be performed at no cost to the owner. Once the dog is confirmed eligible (non-indolent, T-cell lymphoma), all procedures and treatments required by the study including chemotherapy, antibody therapy, exam, bloodwork, and other required diagnostics will be fully funded. Previous studies with this antibody have shown that side effects tend to be minimal, but the study will pay up to $1,200 for medical management of side effects that may occur, either as a result of chemotherapy or monoclonal antibody treatment.

 

Trial Eligibility

To qualify for enrollment, dogs must meet the following criteria:

  • Client-owned dog > 1 year of age
  • Body weight at least 2 kg
  • Biopsy and flow cytometry confirmation of naïve, 
intermediate or high grade T-cell lymphoma
  • Stage II or higher
  • At least one peripherally located lymph node measuring ≥ 2 cm longest diameter
  • Performance Score of 0, 1 or 2 [0 = normal activity; 
1 = restricted activity: decreased activity from
pre disease status; 2 = compromised, ambulatory only for vital activities, consistently defecates and urinates in acceptable areas]

Dogs cannot be enrolled if any of the following conditions are met:

  • Glucocorticoid therapy for more than 7 days prior to enrollment
  • Prior chemotherapy, immunotherapy, or molecular- targeted therapy
  • Any uncontrolled medical condition (including other concurrent malignancy) that may be disruptive to the intent and objectives of the study
  • Dog is pregnant or likely to become pregnant
  • Dog is participating in another study
  • Dog may not be available for the entire study duration

 

Trial Participation

The following veterinary oncology centers are offering this clinical trial:

The Veterinary Cancer Center
129 Glover Ave
Norwalk, CT 06850
(203) 838-6626
New England Veterinary Oncology Group
180 Bear Hill Rd. Suite C
Waltham, MA 02451
(781) 684-8688
The Oncology Service
at The LifeCentre

134 Ft. Evans Rd NE
Leesburg, VA 20176
(571) 209-1176
HOPE Veterinary Specialists
40 Three Tun Road
Malvern, PA 19355
(610) 296-2099
Veterinary Cancer Group

9599 Jefferson Blvd

Culver City, CA 90232

(310) 558-6120
BluePearl Veterinary Partners – Overland Park

11950 West 110th St
Overland Park, KS 66210
(913) 642-9563
Colorado State University
Flint Animal Cancer Center

300 West Drake Road
Fort Collins, CO 80523
(970) 297-4071
Las Vegas Veterinary Specialty Center
8650 W. Tropicana Ave
Suite B-107
Las Vegas, NV 89147
(702) 871-1152
Gulf Coast Veterinary Specialists
1111 W Loop S Fwy #160
Houston, TX 77027
(713) 693-1155
VCA Katonah Bedford Veterinary Center
546 Bedford Rd
Bedford Hills, NY 10507
(914) 241-7700

 

This participating site list will be updated often, so please check again soon.