Posts by catharine

A CLINICAL RESEARCH STUDY FOCUSING ON PAIN MANAGEMENT IN DOGS LIVING WITH OSTEOARTHRITIS OF THE ELBOW

January 17th, 2020 Posted by Pain Management 0 thoughts on “A CLINICAL RESEARCH STUDY FOCUSING ON PAIN MANAGEMENT IN DOGS LIVING WITH OSTEOARTHRITIS OF THE ELBOW”

Trial Overview

This study aims to confirm the effectiveness and safety of a new medicine to control pain associated with osteoarthritis of the elbow in dogs. If your dog qualifies for this study, you should expect to stay in the study for 90 days and have 7 scheduled visits with the veterinarian conducting the study. You will also be required to provide weekly behavioral assessments of your dog.

Because this is a study that is intended to support the drug’s approval, it needs to be “controlled”. This means some dogs receive treatment and others undergo the preparation and everything leading up to an injection of the medication, but do not actually receive the medication being tested. This study is also “blinded” or “masked”, meaning neither you nor the veterinarian making observations will know if your dog received the treatment or not until the end of the study. All owners of the untreated dogs will be given an opportunity at the end of the study for their dogs to receive the investigational treatment at no charge.

More than 200 dogs have been treated with the drug in safety studies, including pet dogs with elbow pain. This study is primarily focused on confirming the effectiveness of the drug. All dogs will be closely monitored and treated, in the event of any side effect. Please feel free to discuss any hesitations with the treating veterinarian, and if at any time prior to treatment you decide not to enroll your dog, you can do so at no charge and with no questions asked.


Trial Eligibility

Trained veterinarians at the trial sites will evaluate each dog for eligibility.

  • At least 1 year old.
  • Weighs more than 11 pounds.
  • Confirmed diagnosis of bilateral elbow pain due to osteoarthritis impacting mobility and quality of life.
  • If suffering from additional conditions other than joint pain, those conditions are stable and under medical care.
  • Is not intended for breeding and is not pregnant or lactating.
  • Has not had a medical or surgical procedure in the past 30 days.

 
*Other study criteria may apply. The veterinary investigator will decide if your dog is a good candidate for this study after examination.*


Trial Funding

If qualified, your dog would receive (at no cost to you):

  • Investigational medicine or the procedure without injection of the medication.
  • Study-related exams and tests.
  • Time with a local veterinarian.


Participating Sites

Veterinary Specialty Hospital
10435 Sorrento Valley Rd, San Diego, CA 92121
Phone: (858) 875-7500

Advanced Care Veterinary Services
1609 West Hebron Parkway; Ste 108, Carrollton, TX 75010
Phone: (972) 394-6422

Limestone Companion Animal Hospital
4224 Airport Rd, Bartonville, IL 61607
Phone: (309) 697-8000

Quakertown Veterinary Clinic
2250 N. Old Bethlehem Pike, Quakertown PA 18951
Phone: (215) 536-6245

Bradford Park Veterinary Hospital
1255 E. Independence, Springfield, MO 65804
Phone: (417) 886-0777

BluePearl Pet Hospital
3000 Busch Lake Blvd, Tampa, FL 33614
Phone: (813) 933-8944

BluePearl Pet Hospital
9500 Marketplace Road, Fort Myers, FL 33912
Phone: (239) 947-0588

Midwestern University Companion Veterinary Clinic
5715 W. Utopia Rd., Room 202, Glendale, AZ 85308
Phone: (623) 806-7387

Veterinary Specialty Hospital of the Carolinas
6405-100 Tryon Road, Cary, NC 27518
Phone: (919) 233-4911

Franklin Animal Clinic
2990 N Morton St, Franklin, IN 46131
Phone: (317) 736-9246

Veterinary Specialty and Emergency Clinic
625 Ridge Pike, Building B, Conshohocken, PA 19428
Phone: (484) 567-7998

Animal Care Center
562 East Castle Pines Pkwy #C5, Castle Rock, CO 80108
Phone: (303) 688-3660

KIDNEY DISEASE SAMPLE COLLECTION PROJECT

January 17th, 2020 Posted by Other 0 thoughts on “KIDNEY DISEASE SAMPLE COLLECTION PROJECT”

Project Overview

The project is being conducted by ACI and involves collection of blood and kidney samples in cats and dogs with all stages of Chronic Kidney Disease (CKD) and/or acute kidney injury (AKI). The objective is to identify differentially expressed genes and over-represented pathways contributing to this disease in pets.


Project Details

Dogs and cats of any breed, age or sex are eligible so long as they are at least 1.5 kg and have CKD or AKI of any IRIS stage.  Prior to enrollment, the owner must provide written consent for participation.  A CBC/Chemistry/Urinalysis will be sent to a central lab before the day of euthanasia or on the day of euthanasia to confirm CKD stage.  There is an option to run in-house bloodwork to confirm the presence of CKD or AKI so long as an additional sample is sent to a central lab for analysis.  Immediately ante-mortem, up to 4ml of blood will be collected for serum and plasma.  These samples will be stored at -20C and eventually batch shipped.  Following euthanasia (within 1 hour), both kidneys will be removed for formalin and RNAlater processing.  These samples will also be batch shipped.

Additionally, the project is designed to collect serum, plasma and kidneys from 15 dogs and 15 cats that are euthanized without having CKD or AKI.  Samples for these pets will also be processed according to the plan above.


Project Compensation

Owner incentive

  • Free euthanasia and cremation
  • Free CBC/chemistry/Urinalysis
  • Donation in pet’s name

 
Site compensation (per case)

  • Blood and urine collection (submit to central lab – collection only)
  • In-house CBC/chemistry if necessary
  • Serum/plasma collection for genetics analysis
  • Serum/plasma sample processing
  • Kidney sample collection (if collected by non-ACI personnel)
  • Kidney sample processing (formalin and RNA storage)
  • Completion of case report forms (if site completes paper only)
  • Completion of case report forms (if entered electronically)
  • ACI will pay for batch shipping of all samples


Participating Sites

Olney Sandy Spring Veterinary Hospital
1300 Olney Sandy Spring Rd.
Sandy Spring, MD 20860
Phone: (301) 774-9500

Quakertown Veterinary Clinic
2250 North Old Bethlehem pike
Quakertown, PA 18951
Phone: (215) 536-6245

Wilson Veterinary Hospital – West
12000 Durham Road
Washington Twp., MI 48095
Phone: (586) 752-6217

Animal Hospital of Dauphin County
241 South Hershey Road
Harrisburg, PA 17112
Phone: (717) 652-1270

Liverpool Animal Health Center
8205 Oswego Rd
Liverpool, NY 13090
Phone: (315) 622-2882

Bradford Park Veterinary Hospital
1255 East Independence St.
Springfield, MO 65804
Phone: (417) 886-0777

AN ECHOCARDIOGRAM AND BLOOD SAMPLE COLLECTION STUDY FOR DOGS WITH DEGENERATIVE MITRAL VALVE DISEASE

February 8th, 2019 Posted by Cardiology, Pain Studies 0 thoughts on “AN ECHOCARDIOGRAM AND BLOOD SAMPLE COLLECTION STUDY FOR DOGS WITH DEGENERATIVE MITRAL VALVE DISEASE”

Project Overview

The project is focused on blood sample collection, and echocardiogram imaging only (not treatment) for dogs with degenerative mitral valve disease (DMVD). Dogs with a suspicious diagnosis, or previous diagnosis, of DMVD will have an echocardiogram, and a single blood sample collection performed.

Dogs are eligible if they meet the following inclusion criteria:

  • Dogs must weigh ≥ 1.5 kg
  • Dogs must be ≥ 2 years of age
  • Dogs must be client-owned
  • Dog must be pure-bred
  • Dogs must be free of uncontrolled inflammatory disease, infections and endocrine disease


Dogs are not eligible if they meet any of the following exclusion criteria:

  • Aggressiveness/intractability such as to make examinations or sampling difficult to perform
  • Females known or suspected to be pregnant or lactating
  • Dog has malignant neoplasia
  • Dog has evidence of heartworm disease


Breeds of interest

Dogs ≤ 20kg that are healthy or with signs of a murmur, DMVD, heart enlargement, or congestive heart failure. The following breeds are of particulate interest:

  • Bichon Frise
  • Boston Terrier
  • Boykin Spaniel
  • Cavalier King Charles Spaniel
  • Chihuahua
  • Cocker Spaniel
  • Dachshund
  • Fox Terrier
  • King Charles Spaniel
  • Lhasa Apso
  • Miniature Pinscher
  • Miniature Schnauzer
  • Pekingese
  • Pomeranian
  • Poodle (toy, miniature)
  • Shetland Sheepdog
  • Shih Tzu
  • West Highland White Terrier
  • Whippet
  • Yorkshire Terrier


Project Funding

Funding includes all procedures required within the one study visit. This includes a physical exam, the echocardiogram, and the one time blood-draw.

Participating Sites

Chesapeake Veterinary Cardiology Associates- Towson
1209 Cromwell Bridge Road
Towson, MD 21286
Phone: (410) 339-3461

Chesapeake Veterinary Cardiology Associates- Annapolis
808 Bestgate Road
Annapolis, MD 21401
Phone: (410) 224-0039

Chesapeake Veterinary Cardiology Associates- Columbia
10,000 Old Columbia Road
Columbia, MD 21046
Phone: (443) 583-3131

Chesapeake Veterinary Cardiology Associates-Rockville
1 Taft Court
Rockville, MD 20850
Phone: (301) 984-5791

Chesapeake Veterinary Cardiology Associates-Gaithersburg
500 Perry Parkway
Gaithersburg, MD 20877
Phone: (240) 361-3820

Chesapeake Veterinary Cardiology Associates-Fairfax
8500 Arlington Blvd.
Fairfax, VA 22031
Phone: (571) 348-3888

Chesapeake Veterinary Cardiology Associates-Leesburg
165 Fort Evans Road NE
Leesburg, VA 20176
Phone: (703) 669-9311

Chesapeake Veterinary Cardiology Associates-Richmond
5918 West Broad Street
Richmond, VA 23230
Phone: (804) 497-8940

Chesapeake Veterinary Cardiology Associates-Vienna
140 Park Street SE
Vienna, VA 22180
Phone: (703) 281-7717

Friendship Hospital for Animals (Non-DMVD dogs only, control group)
4105 Brandywine St. N.W.
Washington, DC 20016
Phone: (202) 363-7300

SEEKING DOGS FOR ENROLLMENT IN A CLINICAL TRIAL EVALUATING A NOVEL THERAPY FOR THE TREATMENT OF TRANSITIONAL CELL CARCINOMA

October 2nd, 2018 Posted by Bladder Cancer, Pain Management, Pain Studies 0 thoughts on “SEEKING DOGS FOR ENROLLMENT IN A CLINICAL TRIAL EVALUATING A NOVEL THERAPY FOR THE TREATMENT OF TRANSITIONAL CELL CARCINOMA”

Trial Specifics

This trial is designed to evaluate the safety and preliminary pain management and effect of a novel therapy in dogs with bladder transitional cell carcinoma (TCC). A secondary goal is to assess potential anti-cancer effect. The trial involves one-time treatment administered directly into the bladder using a urinary catheter. Dogs may receive a second treatment one month after enrollment if warranted. The treatment will be administered under sedation or general anesthesia. There is no placebo in this trial. An estimated 15 client-owned dogs with will be enrolled. Owners will be required to complete quality of life surveys, collect a daily urine sample for visual analysis, and record the urine collection results in a provided journal. The trial site will train the owners on collection and evaluation techniques. Trial visits include the dog’s initial consultation, treatment day (Day 0), and then recheck visits on Days 7, 14, 28, 56, and 84. Anti-cancer therapies must be discontinued 21 days prior to enrollment. Medications targeted at the treatment of TCC-associated pain, except for CBD and other cannabinoids, are acceptable provided they have been administered for at least 2 weeks prior to enrolling in the study.

Trial Funding

The trial is fully funded for the full trial duration (84 days). Funding includes the initial consultation, the study treatment and administration, thoracic radiographs at the beginning and end of the study, monthly abdominal ultrasounds, recheck visits, trial-required bloodwork, and management of side effects that are thought to be directly related to the trial.

Trial Eligibility

Trained veterinarians at the trial sites will evaluate each dog for eligibility.

Dogs are eligible if they meet the following inclusion criteria:

  • Dog presenting with a diagnosis of TCC exclusively associated with the bladder (metastasis is acceptable).
  • Dog with accompanying lower urinary tract clinical signs associated with bladder cancer.
  • Bladder lesion does not prevent the passage of urinary catheter.


Dogs are not eligible if they meet any of the following exclusion criteria:

  • Dog with urethral or prostatic involvement of TCC.
  • Dog has any underlying disease that will affect the study objectives or patient safety.
  • Dog has evidence of hydronephrosis.
  • Dog has an active urinary tract infection (dogs presenting for screening will have a urine culture performed prior to enrollment).
  • Dog has a urethral obstruction.
  • Dog is pregnant or lactating.
  • Dog is participating in another study.

 

This clinical trial is offered at the following locations:

Hope Veterinary Specialists
40 Three Tun Road
Malvern, PA 19355
610-296-2099

Las Vegas Veterinary Specialty Center
8650 W. Tropicana Avenue, Ste. B-107
Las Vegas, NV 89147
702-871-1152

BluePearl Specialty and Emergency
11950 West 110th St
Overland Park, KS 66210
913-642-9563

The Oncology Service – Dogwood
5918 West Broad St
Richmond, VA 23230
804-716-4710

The Veterinary Cancer Center
129 Glover Ave, Norwalk
Norwalk, CT 06850
203-838-6626

Coming Soon

Nothing at this time.