Open Pain Studies Studies

AN ECHOCARDIOGRAM AND BLOOD SAMPLE COLLECTION STUDY FOR DOGS WITH DEGENERATIVE MITRAL VALVE DISEASE

February 8th, 2019 Posted by Cardiology, Pain Studies 0 thoughts on “AN ECHOCARDIOGRAM AND BLOOD SAMPLE COLLECTION STUDY FOR DOGS WITH DEGENERATIVE MITRAL VALVE DISEASE”

Project Overview

The project is focused on blood sample collection, and echocardiogram imaging only (not treatment) for dogs with degenerative mitral valve disease (DMVD). Dogs with a suspicious diagnosis, or previous diagnosis, of DMVD will have an echocardiogram, and a single blood sample collection performed.

Dogs are eligible if they meet the following inclusion criteria:

  • Dogs must weigh ≥ 1.5 kg
  • Dogs must be ≥ 2 years of age
  • Dogs must be client-owned
  • Dog must be pure-bred
  • Dogs must be free of uncontrolled inflammatory disease, infections and endocrine disease


Dogs are not eligible if they meet any of the following exclusion criteria:

  • Aggressiveness/intractability such as to make examinations or sampling difficult to perform
  • Females known or suspected to be pregnant or lactating
  • Dog has malignant neoplasia
  • Dog has evidence of heartworm disease


Breeds of interest

Dogs ≤ 20kg that are healthy or with signs of a murmur, DMVD, heart enlargement, or congestive heart failure. The following breeds are of particulate interest:

  • Bichon Frise
  • Boston Terrier
  • Boykin Spaniel
  • Cavalier King Charles Spaniel
  • Chihuahua
  • Cocker Spaniel
  • Dachshund
  • Fox Terrier
  • King Charles Spaniel
  • Lhasa Apso
  • Miniature Pinscher
  • Miniature Schnauzer
  • Pekingese
  • Pomeranian
  • Poodle (toy, miniature)
  • Shetland Sheepdog
  • Shih Tzu
  • West Highland White Terrier
  • Whippet
  • Yorkshire Terrier


Project Funding

Funding includes all procedures required within the one study visit. This includes a physical exam, the echocardiogram, and the one time blood-draw.

Participating Sites

Chesapeake Veterinary Cardiology Associates- Towson
1209 Cromwell Bridge Road
Towson, MD 21286
Phone: (410) 339-3461

Chesapeake Veterinary Cardiology Associates- Annapolis
808 Bestgate Road
Annapolis, MD 21401
Phone: (410) 224-0039

Chesapeake Veterinary Cardiology Associates- Columbia
10,000 Old Columbia Road
Columbia, MD 21046
Phone: (443) 583-3131

Chesapeake Veterinary Cardiology Associates-Rockville
1 Taft Court
Rockville, MD 20850
Phone: (301) 984-5791

Chesapeake Veterinary Cardiology Associates-Gaithersburg
500 Perry Parkway
Gaithersburg, MD 20877
Phone: (240) 361-3820

Chesapeake Veterinary Cardiology Associates-Fairfax
8500 Arlington Blvd.
Fairfax, VA 22031
Phone: (571) 348-3888

Chesapeake Veterinary Cardiology Associates-Leesburg
165 Fort Evans Road NE
Leesburg, VA 20176
Phone: (703) 669-9311

Chesapeake Veterinary Cardiology Associates-Richmond
5918 West Broad Street
Richmond, VA 23230
Phone: (804) 497-8940

Chesapeake Veterinary Cardiology Associates-Vienna
140 Park Street SE
Vienna, VA 22180
Phone: (703) 281-7717

Friendship Hospital for Animals (Non-DMVD dogs only, control group)
4105 Brandywine St. N.W.
Washington, DC 20016
Phone: (202) 363-7300

SEEKING DOGS FOR ENROLLMENT IN A CLINICAL TRIAL EVALUATING A NOVEL THERAPY FOR THE TREATMENT OF TRANSITIONAL CELL CARCINOMA

October 2nd, 2018 Posted by Bladder Cancer, Pain Management, Pain Studies 0 thoughts on “SEEKING DOGS FOR ENROLLMENT IN A CLINICAL TRIAL EVALUATING A NOVEL THERAPY FOR THE TREATMENT OF TRANSITIONAL CELL CARCINOMA”

Trial Specifics

This trial is designed to evaluate the safety and preliminary pain management and effect of a novel therapy in dogs with bladder transitional cell carcinoma (TCC). A secondary goal is to assess potential anti-cancer effect. The trial involves one-time treatment administered directly into the bladder using a urinary catheter. Dogs may receive a second treatment one month after enrollment if warranted. The treatment will be administered under sedation or general anesthesia. There is no placebo in this trial. An estimated 15 client-owned dogs with will be enrolled. Owners will be required to complete quality of life surveys, collect a daily urine sample for visual analysis, and record the urine collection results in a provided journal. The trial site will train the owners on collection and evaluation techniques. Trial visits include the dog’s initial consultation, treatment day (Day 0), and then recheck visits on Days 7, 14, 28, 56, and 84. Anti-cancer therapies must be discontinued 21 days prior to enrollment. Medications targeted at the treatment of TCC-associated pain, except for CBD and other cannabinoids, are acceptable provided they have been administered for at least 2 weeks prior to enrolling in the study.

Trial Funding

The trial is fully funded for the full trial duration (84 days). Funding includes the initial consultation, the study treatment and administration, thoracic radiographs at the beginning and end of the study, monthly abdominal ultrasounds, recheck visits, trial-required bloodwork, and management of side effects that are thought to be directly related to the trial.

Trial Eligibility

Trained veterinarians at the trial sites will evaluate each dog for eligibility.

Dogs are eligible if they meet the following inclusion criteria:

  • Dog presenting with a diagnosis of TCC exclusively associated with the bladder (metastasis is acceptable).
  • Dog with accompanying lower urinary tract clinical signs associated with bladder cancer.
  • Bladder lesion does not prevent the passage of urinary catheter.


Dogs are not eligible if they meet any of the following exclusion criteria:

  • Dog with urethral or prostatic involvement of TCC.
  • Dog has any underlying disease that will affect the study objectives or patient safety.
  • Dog has evidence of hydronephrosis.
  • Dog has an active urinary tract infection (dogs presenting for screening will have a urine culture performed prior to enrollment).
  • Dog has a urethral obstruction.
  • Dog is pregnant or lactating.
  • Dog is participating in another study.

 

This clinical trial is offered at the following locations:

Hope Veterinary Specialists
40 Three Tun Road
Malvern, PA 19355
610-296-2099

Las Vegas Veterinary Specialty Center
8650 W. Tropicana Avenue, Ste. B-107
Las Vegas, NV 89147
702-871-1152

BluePearl Specialty and Emergency
11950 West 110th St
Overland Park, KS 66210
913-642-9563

The Oncology Service – Dogwood
5918 West Broad St
Richmond, VA 23230
804-716-4710

The Veterinary Cancer Center
129 Glover Ave, Norwalk
Norwalk, CT 06850
203-838-6626

Coming Soon

Nothing at this time.